Resveratrol Works To Simultaneously Remove Circulating Cholesterol And Beta Amyloid Brain Plaque; Mo

A scientific review reveals Resveratrol (rez-vair-aw-troll), known as a red wine molecule, simultaneously removes fatty plaques from arteries and the brain via its ability to control copper.

In 2009 researchers demonstrated Resveratrol's ability to inhibit cholesterol plaque accumulation (atherosclerosis) in arteries by its ability to promote efflux (exit) of cholesterol from the liver rather than interfere with cholesterol production in the liver as statin drugs do. Via its ability to bind with copper, Resveratrol negates unbound copper's susceptibility to harden cholesterol and form arterial plaque.

In a lab dish, Resveratrol's ability to reduce oxidation (hardening) of cholesterol (LDL- low-density lipoproteins) was found to be mainly due to its capacity to chelate copper.

Earlier studies, conducted in the late 1990s, show that trans Resveratrol, but to a much lesser extent cis resveratrol (its less active molecular cousin that has been altered due to exposure to UV light), works to prevent oxidation of lipoproteins (protein-bound cholesterol) at very low concentration. It was found that low-dose trans resveratrol is by far the most potent chelators of copper. It may contribute to the protective effects of wine by removal of copper from LDL particles and arterial tissue.

Resveratrol appears to reduce fatty deposits in arteries at relative low dose, about the amount provided in 3 glasses of dark red wine (180-300 mg). Quercetin works even better in this regard and is a good companion to resveratrol.

This may help explain why Resveratrol was found to reduce arterial plaque formation in arteries without lowering circulating cholesterol numbers in animals. In fact, with more cholesterol exiting the body, it may even raise circulating levels of cholesterol.

In a similar fashion, Resveratrol is believed to accelerate removal of cholesterol plaque (beta amyloid) from the brain rather than inhibit its production.

In 2007 researchers also showed that HDL cholesterol complexes with beta amyloid plaque to remove it from the brain and final disposal through its exit from the liver. Resveratrol has been shown to raise HDL cholesterol and reduce beta amyloid in animal brains.

Credits: Bill Sardi (